Oxidative damage in mitochondrial DNA is not extensive

Authors

Kok Seong Lim
Kandiah Jeyaseelan
Matthew Whiteman, National University of Singapore
Andrew M. Jenner, University of WollongongFollow
Barry Halliwell, National University of SingaporeFollow

RIS ID

39049

Publication Details

Lim, K. Seong., Jeyaseelan, K., Whiteman, M., Jenner, A. M. & Halliwell, B. (2005). Oxidative damage in mitochondrial DNA is not extensive. Annals of the New York Academy of Sciences, 1042 210-220.

Abstract

Since 1988 several research groups have reported greater levels of oxidative damage in mitochondrial DNA than in nuclear DNA, while others have suggested that the greater damage in mtDNA might be due to artifactual oxidation. The popular theory that mtDNA is more heavily damaged in vivo than nDNA does not stand on firm ground. Using an improved GC-MS method and pure mtDNA, our analyses revealed that the damage level in mtDNA is not higher, and may be somewhat lower, than that in nDNA. © 2005 New York Academy of Sciences.