Preimplantation exposure to Bisphenol A and Triclosan may lead to implantation failure in humans

Authors

Mu Yuan, Zhejiang University
Ming-Zhu Bai, Shanghai Jiaotong University
Xu-Feng Huang, University of WollongongFollow
Yue Zhang, Zhejiang University
Jing Liu, Zhejiang University
Min-Hao Hu, Zhejiang University
Wei-Qian Zheng, Zhejiang University
Fan Jin, Zhejiang University

RIS ID

101645

Publication Details

Yuan, M., Bai, M., Huang, X., Zhang, Y., Liu, J., Hu, M., Zheng, W. & Jin, F. (2015). Preimplantation exposure to Bisphenol A and Triclosan may lead to implantation failure in humans. BioMed Research International, 2015 184845-1-184845-9.

Link to publisher version (URL)

BioMed Research International

Abstract

Endocrine disrupting chemicals (EDCs) are chemicals that have the capacity to interfere with normal endocrine systems. Two EDCs, bisphenol A (BPA) and triclosan (TCS), are mass-produced and are widespread.They both have estrogenic properties and similar chemical structures and pharmacokinetic features and have been detected in human fluids and tissues. Clinical evidence has suggested a positive association between BPA exposure and implantation failure in IVF patients. Studies inmouse models have suggested that preimplantation exposure to BPA and TCS can lead to implantation failure. This paper reviews the relationship between preimplantation exposure to BPA and TCS and implantation failure and discusses the remaining problems and possible solutions.