No support for an association with TAAR6 and schizophrenia in a linked population of European ancestry

Authors

Herbert P. Ludewick, University of Western Australia
Sibylle G. Schwab, University of Western AustraliaFollow
Margot Albus, Mental State Hospital
Bernard Lerer, Stanford University
Wolfgang Maier, University of Bonn
Matyas Trixler, University of Pecs, Hungary
Dieter B. Wildenauer, University of Western Australia

RIS ID

97602

Publication Details

Ludewick, H. P., Schwab, S. G., Albus, M., Lerer, B., Maier, W., Trixler, M. & Wildenauer, D. B. (2008). No support for an association with TAAR6 and schizophrenia in a linked population of European ancestry. Psychiatric Genetics, 18 (4), 208-210.

Abstract

Single nucleotide polymorphisms (SNPs) in the trace amine associated receptor trace amine associated receptor 6 gene and 3' flanking region have been shown to be associated with schizophrenia. To replicate these findings, we conducted a family-based association study with the five most significant SNPs in our sample of 79 sib-pair families (56/79 sib-pair families showed linkage to 6q23) and 125 triads. No evidence for association was obtained between these SNPs and schizophrenia in our sample, even when limited to the 56 linked families (P>0.2). We conclude that trace amine associated receptor 6 is not important for the development of schizophrenia in our family samples.