A family-based association study of DNA sequence variants in GRM7 with schizophrenia in an Indonesian population

Authors

Clarissa Ganda, University of Western Australia
Sibylle G. Schwab, University of Western AustraliaFollow
Nurmiati Amir, University of Indonesia
Heriani Heriani, University of Indonesia
Irmansyah Irmansyah, University of Indonesia
Agung A.A.A Kusumawardhani, University of Indonesia
Martina W. Nasrun, University of Indonesia
Ika Widyawati, University of Indonesia
Wolfgang Maier, University of Bonn
Dieter B. Wildenauer, University of Western Australia

RIS ID

95775

Publication Details

Ganda, C., Schwab, S. G., Amir, N., Heriani, H., Irmansyah, I., Kusumawardhani, A., Nasrun, M., Widyawati, I., Maier, W. & Wildenauer, D. B. (2009). A family-based association study of DNA sequence variants in GRM7 with schizophrenia in an Indonesian population. International Journal of Neuropsychopharmacology, 12 (9), 1283-1289.

Abstract

We previously reported genome-wide significant linkage to chromosome 3p in a sib-pair family sample from Indonesia. A promising candidate gene within the linked region is the metabotropic glutamate receptor subtype 7 (GRM7), involved in glutamatergic neurotransmission. We genotyped 18 single nucleotide polymorphisms in GRM7 in the sample of 124 Indonesian sib-pair families that had provided the significant linkage finding. Transmission disequilibrium analysis revealed nominally significant transmission distortion of rs17031835 in intron 1 of GRM7 (p=0.004, before correction for multiple testing), along with haplotypes containing rs17031835. No other single marker was found to be significantly associated with schizophrenia in our sample. The results from our study provide support for the idea that glutamatergic neurotransmission and specifically the GRM7 gene might be relevant to the development of schizophrenia. Further studies supporting this finding are warranted.