Title

Characterizing the role of tissue-type plasminogen activator in a mouse model of Group A streptococcal infection

RIS ID

135273

Publication Details

Ly, D., Donahue, D., Walker, M. J., Ploplis, V. A., McArthur, J. D., Ranson, M., Castellino, F. J. & Sanderson-Smith, M. L. (2019). Characterizing the role of tissue-type plasminogen activator in a mouse model of Group A streptococcal infection. Microbes and Infection: a journal on infectious agents and host defenses, 21 (8-9), 412-417.

Abstract

Plasmin(ogen) acquisition is critical for invasive disease initiation by Streptococcus pyogenes (GAS). Host urokinase plasminogen activator (uPA) plays a role in mediating plasminogen activation for GAS dissemination, however the contribution of tissue-type plasminogen activator (tPA) to GAS virulence is unknown. Using novel tPA-deficient ALBPLG1 mice, our study revealed no difference in mouse survival, bacterial dissemination or the pathology of GAS infection in the absence of tPA in AlbPLG1/tPA−/− mice compared to AlbPLG1 mice. This study suggests that tPA has a limited role in this humanized model of GAS infection, further highlighting the importance of its counterpart uPA in GAS disease.

Grant Number

NHMRC/635218

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