Overcoming original antigenic sin to generate new CD8 T cell IFN-y responses in an antigen-experienced host
RIS ID
49850
Abstract
The failure to mount effective immunity to virus variants in a previously virus-infected host is known as original antigenic sin. We have previously shown that prior immunity to a virus capsid protein inhibits induction by immunization of an IFN-?? CD8+ T cell response to an epitope linked to the capsid protein. We now demonstrate that capsid protein-primed CD4+ T cells secrete IL-10 in response to capsid protein presented by dendritic cells, and deviate CD8+ T cells responding to a linked MHC class I-restricted epitope to reduce IFN-?? production. Neutralizing IL-10 while delivering further linked epitope, either in vitro or in vivo, restores induction by immunization of an Ag-specific IFN-?? response to the epitope. This finding demonstrates a strategy for overcoming inhibition of MHC class I epitopes upon immunization of a host already primed to Ag, which may facilitate immunotherapy for chronic viral infection or cancer. Copyright ?? 2006 by The American Association of Immunologists, Inc.
Publication Details
Liu, X., Dyer, J., Leggatt, G. R., Fernando, G. J P., Zhong, J., Thomas, R. & Frazer, I. H. (2006). Overcoming original antigenic sin to generate new CD8 T cell IFN-y responses in an antigen-experienced host. Journal of Immunology, 177 (5), 2873-2879.