Vertical Nanowire Electrode Arrays as Novel Electrochemical Label-Free Immunosensors

Authors

Babak Nasr, University of Melbourne
Gursharan Chana, University of Melbourne
Ting Ting Lee, University of Melbourne
Thanh Nguyen, University of Melbourne
Chathurika Abeyrathne, University of Melbourne
Giovanna M. D'Abaco, University of Melbourne
Mirella Dottori, University of MelbourneFollow
Efstratios Skafidas, University of Melbourne

RIS ID

117758

Publication Details

Nasr, B., Chana, G., Lee, T., Nguyen, T., Abeyrathne, C., D'Abaco, G. M., Dottori, M. & Skafidas, E. (2015). Vertical Nanowire Electrode Arrays as Novel Electrochemical Label-Free Immunosensors. Small, 11 (24), 2862-2868.

Abstract

A new method for the fabrication of a label-free electrochemical immunosensor based on vertical nanowires (VNWs) is proposed. The VNWs are functionalized to detect antibodies against a major astrocytic structural protein component, glial fibrillary acidic protein (GFAP). It is revealed that the interaction of GFAP-antibody with functionalized VNWs leads to a clear change in device conductance and the corresponding capacitance.