Effects of olanzapine and betahistine on serotonin 5-HT2A receptor binding in the rat brain

Authors

Jiamei Lian, University of WollongongFollow
Xu-Feng Huang, University of WollongongFollow
N Pai, University of WollongongFollow
C Deng, University of WollongongFollow

RIS ID

64910

Publication Details

Lian, J., Huang, X., Pai, N. & Deng, C. (2012). Effects of olanzapine and betahistine on serotonin 5-HT2A receptor binding in the rat brain. ANS 2012: Australian Neuroscience Society 31st Annual meeting (p. 97). Australia: ANS.

Abstract

Olanzapine is widely used in treating multiple domains of schizophrenia symptoms through its binding profile to various neurotransmitter receptors including a high antagonistic affinity to serotonergic 5-HT2A receptors (5-HT2AR). On the other hand, antagonistic affinity of olanzapine to histamine H1 receptors is a main indicator of its weight gain/obesity side effects.