EEG coherence and symptom profiles of children with Attention-Deficit/Hyperactivity Disorder



Publication Details

Barry, R. J., Clarke, A. R., Hajos, M., Dupuy, F. E., McCarthy, R. & Selikowitz, M. (2011). EEG coherence and symptom profiles of children with Attention-Deficit/Hyperactivity Disorder. Clinical Neurophysiology, 122 (7), 1327-1332.


Objective: We compared EEG coherence in children with and without AD/HD, and sought to relateobserved anomalies to AD/HD symptoms.Methods: Forty children with AD/HD and 40 age- and sex-matched controls had eyes-closed resting EEGcoherence calculated for eight interhemispheric electrode pairs and eight intrahemispheric pairs (fourwithin each hemisphere) in the delta, theta, alpha, beta and ``40 Hz¿¿ gamma bands.Results: At short-medium inter-electrode distances, the AD/HD group had increased intrahemisphericcoherence in delta and theta, and reduced (L > R) laterality in delta, alpha, beta and gamma. Over longerinter-electrode distances, the AD/HD group had reduced intrahemispheric coherence in alpha. In interhemisphericcomparisons, the AD/HD group had reduced frontal coherence in delta, alpha and gamma,increased temporal theta and reduced temporal alpha coherences, and increased central/parietal/occipitalcoherence in theta. Smaller left-lateralized coherences in AD/HD correlated negatively with DSM Inattentiveand DSM Total scores, and smaller frontal interhemispheric coherence in alpha correlatednegatively with DSM Hyperactive/Impulsive score.Conclusions: The negative correlations between AD/HD coherence anomalies and symptoms suggest thatseveral anomalies reflect compensatory brain function.Significance: Coherence differences in AD/HD may reflect anomalous frontal right-hemisphere linkagesthat help compensate functional brain anomalies in the left frontal regions in this disorder. 2011 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd.

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