EEG coherence and symptom profiles of children with Attention-Deficit/Hyperactivity Disorder
RIS ID
42785
Abstract
Objective: We compared EEG coherence in children with and without AD/HD, and sought to relateobserved anomalies to AD/HD symptoms.Methods: Forty children with AD/HD and 40 age- and sex-matched controls had eyes-closed resting EEGcoherence calculated for eight interhemispheric electrode pairs and eight intrahemispheric pairs (fourwithin each hemisphere) in the delta, theta, alpha, beta and ``40 Hzÿÿ gamma bands.Results: At short-medium inter-electrode distances, the AD/HD group had increased intrahemisphericcoherence in delta and theta, and reduced (L > R) laterality in delta, alpha, beta and gamma. Over longerinter-electrode distances, the AD/HD group had reduced intrahemispheric coherence in alpha. In interhemisphericcomparisons, the AD/HD group had reduced frontal coherence in delta, alpha and gamma,increased temporal theta and reduced temporal alpha coherences, and increased central/parietal/occipitalcoherence in theta. Smaller left-lateralized coherences in AD/HD correlated negatively with DSM Inattentiveand DSM Total scores, and smaller frontal interhemispheric coherence in alpha correlatednegatively with DSM Hyperactive/Impulsive score.Conclusions: The negative correlations between AD/HD coherence anomalies and symptoms suggest thatseveral anomalies reflect compensatory brain function.Significance: Coherence differences in AD/HD may reflect anomalous frontal right-hemisphere linkagesthat help compensate functional brain anomalies in the left frontal regions in this disorder. 2011 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd.
Publication Details
Barry, R. J., Clarke, A. R., Hajos, M., Dupuy, F. E., McCarthy, R. & Selikowitz, M. (2011). EEG coherence and symptom profiles of children with Attention-Deficit/Hyperactivity Disorder. Clinical Neurophysiology, 122 (7), 1327-1332.