Soy food consumption does not lower LDL cholesterol in either equol or nonequol producers



Publication Details

Hodgson, J., Buckley, J. D., Mansour, J., Meyer, B. J., Howe, P., Coates, A. M., Thorp, A. A. & Mori, T. 2008, ''Soy food consumption does not lower LDL cholesterol in either equol or nonequol producers'', American Journal of Clinical Nutrition, vol. 88, no. 2, pp. 298-304.


Background: Health claims link soy protein (SP) consumption, through plasma cholesterol reduction, to a decreased risk of heart disease. Soy isoflavones (ISOs), particularly in individuals who produce equol, might also contribute to lipid lowering and thus reduce SP requirements.Objective: The objective was to examine the contributions of SP, ISOs, and equol to the hypocholesterolemic effects of soy foods.Design: Nonsoy consumers (33 men, 58 women) with a plasma total cholesterol (TChol) concentration 5.5 mmol/L participated in a double-blind, placebo-controlled, crossover intervention trial. Thesubjects consumed 3 diets for 6 wk each in random order, which consisted of foods providing a daily dose of 1) 24gSPand7080mg ISOs (diet S); 2) 12 g SP, 12 g dairy protein (DP), and 7080 mgISOs (diet SD); and 3) 24 gDPwithout ISOs (diet D). Fasting plasma TChol, LDL cholesterol, HDL cholesterol, and triglycerides (TGs) were measured after each diet.Results: TChol was 3% lower with the S diet (0.17 0.06 mmol/L;P0.05) than with theDdiet, andTGswere4%lower with both the S (0.140.05 mmol/L; P0.05) and SD (0.120.05mmol/L; P 0.05) diets. There were no significant effects on LDL cholesterol, HDL cholesterol, or the TChol:HDL cholesterol ratio. On the basis of urinary ISOs, 30 subjects were equol producers. Lipids were not affected significantly by equol production.Conclusions: Regular consumption of foods providing 24 g SP/d from ISOs had no significant effect on plasma LDL cholesterol in mildly hypercholesterolemic subjects, regardless of equolproducing status. Am J Clin Nutr 2008;88:298 304.

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