Comp plan: A computer program to generate dose and radiobiological metrics from dose-volume histogram files

Authors

Lois Charlotte Holloway, University of WollongongFollow
Julie-Anne Miller, University of Sydney,,Liverpool & Macarthur Cancer Therapy Centre
Shivani Kumar, Cancer Therapy Centre Liverpool Hospital
Brendan M. Whelan, The University Of Sydney
Shalini K. Vinod, Liverpool Hospital,University Of New South Wales

RIS ID

63506

Publication Details

Holloway, L. Charlotte., Miller, J., Kumar, S., Whelan, B. M. & Vinod, S. K. (2012). Comp Plan: A computer program to generate dose and radiobiological metrics from dose-volume histogram files. Medical Dosimetry, 37 (3), 305-309.

Abstract

Treatment planning studies often require the calculation of a large number of dose and radiobiological metrics. To streamline these calculations, a computer program called Comp Plan was developed using MATLAB. Comp Plan calculates common metrics, including equivalent uniform dose, tumor control probability, and normal tissue complication probability from dose-volume histogram data. The dose and radiobiological metrics can be calculated for the original data or for an adjusted fraction size using the linear quadratic model. A homogeneous boost dose can be added to a given structure if desired. The final output is written to an Excel file in a format convenient for further statistical analysis. Comp Plan was verified by independent calculations. A lung treatment planning study comparing 45 plans for 7 structures using up to 6 metrics for each structure was successfully analyzed within approximately 5 minutes with Comp Plan. The code is freely available from the authors on request.