Thermo-responsive polymer-functionalized mesoporous carbon for controlled drug release

Authors

Shenmin Zhu, Shanghai Jiao Tong University, Dongchuan Road, Shanghai
Chenxin Chen, State Key Lab Metal Matrix Comp Shanghai
Zhixin Chen, University of WollongongFollow
Xinye Liu, Shanghai Jiao Tong University, Shanghai
Yao Li, State Key Laboratory of Metal Matrix Composites
Yang Shi, State Key Laboratories of Metal Matrix Composites
Di Zhang, Shanghai Jiao Tong University, 800 Dongchuan Road, ShanghaiFollow

RIS ID

35312

Publication Details

Zhu, S., Chen, C., Chen, Z., Liu, X., Li, Y., Shi, Y. and Zhang, D. (2011). Thermo-responsive polymer-functionalized mesoporous carbon for controlled drug release. Materials Chemistry and Physics, 126 (1-2), 357-363.

Abstract

A novel responsive drug delivery system based on poly(N-isopropyl acrylamide) (PNIPAM) functionalized ordered mesoporous carbon (CMK-3) is developed. The polymer-functionalized CMK-3 was obtained by a combination of simple surface modification of CMK-3 and in situ internal polymerization of PNIPAM. The formation of the PNIPAM inside the CMK-3 was confirmed by thermal gravimetric analysis, Fourier transform-infrared spectroscopy, scanning and transmission electron microscopy and N₂ adsorption/desorption measurements. Controlled drug release tests through the porous network of the PNIPAM functionalized CMK-3 were carried out by measuring the uptake and release of ibuprofen in vitro. The release profiles exhibited a pronounced transition at around 20–25 °C. This thermo-sensitive release property of this delivery system was further confirmed by temperature-variable hydrogen nuclear magnetic resonance analysis. The internal PNIPAM layers acted as a storage gate as well as a release switch in response to the stimuli of environment.