In vitro anticancer activity of doxorubicin-loaded gelatin-coated magnetic iron oxide nanoparticles

Authors

Babita Gaihre, University of WollongongFollow
M. S. Khil
H. Y. Kim

RIS ID

42250

Publication Details

Gaihre, B., Khil, M. S. Kim, H. Y. (2011). In vitro anticancer activity of doxorubicin-loaded gelatin-coated magnetic iron oxide nanoparticles. Journal of Microencapsulation, 28 (4), 286-293.

Abstract

Magnetic drug targeting allows accumulation of drug at a defined target site with the help of an external magnetic field. Current research explored uptake and anticancer activity of doxorubicin-loaded gelatin-coated magnetic iron oxide particles (DXR-GIOPs) in order to investigate potential of gelatin-coated iron oxide particles (GIOPs) as a drug carrier in the field of magnetic drug targeting. The in vitro test was done using HeLa cells as a model cell and DXR as a model drug. The cytotoxicity and uptake of GIOPs were also studied and results were compared with that of DXR-GIOPs. The results indicated that GIOPs were not toxic to HeLa cells even at higher concentration of 1.2 mg/mL; however, DXR-GIOPs showed toxicity in time as well as dose-dependent manner. Furthermore, quantitative and qualitative uptake studies showed higher uptake of DXR-GIOPs compared to GIOPs in the identical condition by the cells.