Radioactive synthesis and biodistribution study of β-elemene- 99mTc(CO)3 conjugates
RIS ID
79237
Abstract
β-Elemene, (5S,7R,10S)-(−)-(1-methyl-1-vinyl-2,4-diisopropenylcyclohexane), is an anticancer agent from traditional Chinese herbal medicine. Three novel 99mTc(CO)3-β-elemene conjugates were synthesized successfully, and compared with β-elemene exhibited improved water solubility. A biodistribution and micro single photon emission computed tomography image study showed there is a visible accumulation in Lewis lung cancer tumors.
Publication Details
Sun, Y., Ren, Y., Zhu, H., Zhang, Y., Liu, G., Zhang, C., Huang, L., Xu, J., Qi, Y. & Shen, Y. (2009). Radioactive synthesis and biodistribution study of β-elemene- 99mTc(CO)3 conjugates. Journal of Biological Inorganic Chemistry, 14 (6), 899-904.