Publication Details

Chartier, L., Tran, L. T., Bolst, D., Pogossov, A., Guatelli, S., Petasecca, M., Lerch, M., Prokopovich, D., Reinhard, M., Perevertaylo, V., Jackson, M., Matsufuji, N. & Rosenfeld, A. B. (2017). New silicon microdosimetry probes for RBE and biological dose studies using stationary and movable targets in 12C ion therapy. Journal of Physics: Conference Series, 777 (1), 012019-1-012019-4.


Due to the high LET and dense ionisation tracks associated with ions, microdosimetric approaches have been used in carbon ion therapy to assess field quality and calculate radiobiological quantities for a variety of cell lines. There is however a lack of instrumentation for simple and routine use in a clinical environment, important for determination of RBE which provides accurate treatment planning and delivery in hadron therapy. In this study, a 10 μm thick silicon microdosimeter with 3D sensitive volumes has been used to investigate the effect of motion on the RBE and field quality of a typical 12C ion therapy beam. For a passively scattered 290 MeV/u 12C beam with 6 cm spread-out Bragg peak (SOBP), variations in biological dose along the SOBP were observed, as well as a significant changes to particle LET when incident on a moving target.



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