New silicon microdosimetry probes for RBE and biological dose studies using stationary and movable targets in ¹²C ion therapy

Authors

Lachlan Chartier, University of WollongongFollow
Linh T. Tran, University of WollongongFollow
David Bolst, University of WollongongFollow
Alex Pogossov, University of Wollongong
Susanna Guatelli, University of WollongongFollow
Marco Petasecca, University of WollongongFollow
Michael L. F Lerch, University of WollongongFollow
Dale A. Prokopovich, University of WollongongFollow
Mark I. Reinhard, ANSTO
Vladimir Perevertaylo, SPA BIT
Michael A. Jackson, University of Wollongong
Naruhiro Matsufuji, National Institute of Radiological SciencesFollow
Anatoly B. Rosenfeld, University of WollongongFollow

RIS ID

112818

Publication Details

Chartier, L., Tran, L. T., Bolst, D., Pogossov, A., Guatelli, S., Petasecca, M., Lerch, M., Prokopovich, D., Reinhard, M., Perevertaylo, V., Jackson, M., Matsufuji, N. & Rosenfeld, A. B. (2017). New silicon microdosimetry probes for RBE and biological dose studies using stationary and movable targets in ¹²C ion therapy. Journal of Physics: Conference Series, 777 (1), 012019-1-012019-4.

Abstract

Due to the high LET and dense ionisation tracks associated with ions, microdosimetric approaches have been used in carbon ion therapy to assess field quality and calculate radiobiological quantities for a variety of cell lines. There is however a lack of instrumentation for simple and routine use in a clinical environment, important for determination of RBE which provides accurate treatment planning and delivery in hadron therapy. In this study, a 10 μm thick silicon microdosimeter with 3D sensitive volumes has been used to investigate the effect of motion on the RBE and field quality of a typical ¹²C ion therapy beam. For a passively scattered 290 MeV/u ¹²C beam with 6 cm spread-out Bragg peak (SOBP), variations in biological dose along the SOBP were observed, as well as a significant changes to particle LET when incident on a moving target.