Design optimization and evaluation of a human brain SPECT-MRI insert based on high-resolution detectors and slit-slat collimators

RIS ID

91940

Publication Details

Erlandsson, K., Salvado, D., Bousse, A. & Hutton, B. F. (2013). Design optimization and evaluation of a human brain SPECT-MRI insert based on high-resolution detectors and slit-slat collimators. IEEE Nuclear Science Symposium and Medical Imaging Conference (pp. 1-4). United States: IEEE.

Abstract

Multi-modality scanners have become increasingly popular in recent years. While PET/CT, SPECT/CT and PET/MRI systems are now commercially available, SPECT/MRI systems are still in a development phase. The aim of this work was to design a SPECT insert for a conventional MRI scanner in order to perform simultaneous SPECT/MRI studies. The SPECT system will consist of a stationary ring of detectors equipped with multi-pinhole or slit-slat collimators. The detector ring will contain multiple small scintillation detectors with Si-based optical readout units. We have investigated a series of design options using analytical calculations of resolution and sensitivity as well as simulations based on various digital phantoms. Our results show that the highest sensitivity is achieved with a multi-pinhole collimator with 2x2 pinholes per detector. However, due to artifacts appearing as a result of cross-talk related to the parallax effect, a better solution could be the 2-slit slit-slat system, with only 5% lower sensitivity. With a target resolution of 10 mm FWHM, the mean sensitivity over a central ROI for this system was 6.30·10-4.

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Link to publisher version (DOI)

http://dx.doi.org/10.1109/NSSMIC.2013.6829144