Cross-sectional and longitudinal analysis of the relationship between AB deposition, cortical thickness and memory in cognitively unimpaired individuals and in Alzheimer disease

Authors

Vincent Dore, Royal Brisbane and Women's Hospital
Victor L. Villemagne, University of Melbourne
Pierrick Bourgeat, Royal Brisbane and Women's Hospital
Jurgen Fripp, Royal Brisbane and Women's Hospital
Oscar Acosta, Université de Rennes
Gael Chetelat, Universite de Caen
Luping Zhou, University of WollongongFollow
Ralph Martins, Edith Cowan University
Kathryn A. Ellis, University of Melbourne
Colin L. Masters, University Of Melbourne
David Ames, CSIRO
Oliver Salvado, Royal Brisbane and Women's Hospital
Christopher C. Rowe, University of Melbourne

RIS ID

76397

Publication Details

Dore, V., Villemagne, V. L., Bourgeat, P., Fripp, J., Acosta, O., Chetelat, G., Zhou, L., Martins, R., Ellis, K. A., Masters, C. L., Ames, D., Salvado, O. & Rowe, C. C. (2013). Cross-sectional and longitudinal analysis of the relationship between AB deposition, cortical thickness and memory in cognitively unimpaired individuals and in Alzheimer disease. JAMA Neurology, 70 (7), 903-911.

Abstract

Importance β-amyloid (Aβ) deposition is one of the hallmarks of Alzheimer disease. Aβ deposition accelerates gray matter atrophy at early stages of the disease even before objective cognitive impairment is manifested. Identification of at-risk individuals at the presymptomatic stage has become a major research interest because it will allow early therapeutic interventions before irreversible synaptic and neuronal loss occur. We aimed to further characterize the cross-sectional and longitudinal relationship between Aβ deposition, gray matter atrophy, and cognitive impairment.