Additional support for linkage of schizophrenia and bipolar disorder to chromosome 3q29

Authors

Alexandra Schosser, Medical University Vienna
K Fuchs, Medical University Vienna
Theresa Scharl, Vienna University of Technology
Friedrich Leisch, Vienna University of Technology
Ursula Bailer, Medical University Vienna
Siegfried Kasper, Medical University Vienna
Werner Sieghart, Medical University Vienna
Kurt Hornik, Vienna University of Economics and Business Administration
Harald N. Aschauer, Medical University Vienna

RIS ID

22670

Publication Details

Schosser, A., Fuchs, K., Scharl, T., Leisch, F., Bailer, U., Kasper, S., Sieghart, W., Hornik, K. & Aschauer, H. N. (2007). Additional support for linkage of schizophrenia and bipolar disorder to chromosome 3q29. European Neuropsychopharmacology, 17 (6-7), 501-505.

Abstract

After publishing a genome scan and follow-up fine mapping, suggesting schizophreniaand bipolar disorder linkage to chromosome 3q29, we now genotyped 11 additional SNPs (singlenucleotide polymorphisms), in order to narrow down a potential candidate region. Linkage wasperformed using the GENEHUNTER program version 2.1r3. A NPL score Zall of 3.891 (p=0.000156)was observed with SNP rs225. In short, we found significant linkage scores most telomeric onchromosome 3q29, spanning 3.46 Mbp (7 SNPs).