Ultrasmall manganese ferrite nanoparticles as positive contrast agent for magnetic resonance imaging

Authors

Zhen Li, University of WollongongFollow
Shu Xia Wang, Chinese Academy Of Sciences
Qiao Sun, University Of Queensland
Hong Li Zhao, University Of Science And Technology Of China
Hao Lei, Chinese Academy Of Sciences
Min Bo Lan, East China University of Science and Technology
Zhenxiang Cheng, University of WollongongFollow
Xiaolin Wang, University of WollongongFollow
S X. Dou, University of WollongongFollow
Gao Qing (Max) Lu, University Of QueenslandFollow

RIS ID

80738

Publication Details

Li, Z., Wang, S. Xia., Sun, Q., Zhao, H. Li., Lei, H., Lan, M. Bo., Cheng, Z., Wang, X., Dou, S. X. & Lu, G. (2013). Ultrasmall manganese ferrite nanoparticles as positive contrast agent for magnetic resonance imaging. Advanced Healthcare Materials, 2 (7), 958-964.

Abstract

Magnetic resonance imaging (MRI) has been extensively used as a powerful noninvasive tool in patient healthcare under the assistance of Ti-positive agents or T2-negative agents. The T1-positive agents have distinct signal-enhancing ability to produce higher image contrast and higher spacial resolution in comparison with T2-negative agents which can lower image contrast because their negative signals are often confused with the signals from bleeding, calcification, metal deposits and susceptibility artifacts. The currently clinically used T1-positive agents are dominant with paramagnetic gadolinium (Gd3+) complexes. However the recent discovery of nephrogenic systemic fibrosis (NSF) arisen from Gd-agents in some patients has fostered concerns and restrictions on their clinical use. The pursuit of alternative T1-positive agents has renewed attention given to manganese-based contrast agents.