Title

3D printing of nanocellulose hydrogel scaffolds with tunable mechanical strength towards wound healing application

RIS ID

131705

Publication Details

Xu, C., Zhang Molino, B., Wang, X., Cheng, F., Xu, W., Molino, P., Bacher, M., Su, D., Rosenau, T., Willfor, S. & Wallace, G. (2018). 3D printing of nanocellulose hydrogel scaffolds with tunable mechanical strength towards wound healing application. Journal of Materials Chemistry B, 6 (43), 7066-7075.

Abstract

We present for the first time approaches to 3D-printing of nanocellulose hydrogel scaffolds based on double crosslinking, first by in situ Ca2+ crosslinking and post-printing by chemical crosslinking with 1,4-butanediol diglycidyl ether (BDDE). Scaffolds were successfully printed from 1% nanocellulose hydrogels, with their mechanical strength being tunable in the range of 3 to 8 kPa. Cell tests suggest that the 3D-printed and BDDE-crosslinked nanocellulose hydrogel scaffolds supported fibroblast cells' proliferation, which was improving with increasing rigidity. These 3D-printed scaffolds render nanocellulose a new member of the family of promising support structures for crucial cellular processes during wound healing, regeneration and tissue repair.

Grant Number

ARC/CE140100012

Please refer to publisher version or contact your library.

Share

COinS