Three-dimensional neural cultures produce networks that mimic native brain activity

Authors

Justin L. Bourke, University of MelbourneFollow
Anita F. Quigley, University of WollongongFollow
Serena Duchi, University of Wollongong
Cathal D. O'Connell, University of WollongongFollow
Jeremy Micah Crook, University of WollongongFollow
Gordon G. Wallace, University of WollongongFollow
Mark J. Cook, University of MelbourneFollow
Robert M. I Kapsa, University of WollongongFollow

RIS ID

122059

Publication Details

Bourke, J. L., Quigley, A. F., Duchi, S., O'Connell, C. D., Crook, J. M., Wallace, G. G., Cook, M. J. & Kapsa, R. (2018). Three-dimensional neural cultures produce networks that mimic native brain activity. Journal of Tissue Engineering and Regenerative Medicine, 12 (2), 490-493.

Abstract

Development of brain function is critically dependent on neuronal networks organized through three dimensions. Culture of central nervous system neurons has traditionally been limited to two dimensions, restricting growth patterns and network formation to a single plane. Here, with the use of multichannel extracellular microelectrode arrays, we demonstrate that neurons cultured in a true three-dimensional environment recapitulate native neuronal network formation and produce functional outcomes more akin to in vivo neuronal network activity.

Grant Number

ARC/CE140100012

Grant Number

NHMRC/1062569