Synthesis and cytotoxicity of dendritic platinum nanoparticles with HEK-293 cells

Authors

Kyubin Shim, University of WollongongFollow
Jeonghun Kim, University of WollongongFollow
Yoon-Uk Heo, Pohang University of Science and Technology
Bo Jiang, Waseda University, National Institute for Materials Science, JapanFollow
Cuiling Li, National Institute for Materials Science, JapanFollow
Mohammed Shahabuddin, King Saud University, Jamia Millia Islamia University, New Delhi
Kevin C.-W Wu, National Taiwan UniversityFollow
Md Shahriar Hossain, University of WollongongFollow
Yusuke Yamauchi, University of WollongongFollow
Jung Ho Kim, University of WollongongFollow

RIS ID

110995

Publication Details

Shim, K., Kim, J., Heo, Y., Jiang, B., Li, C., Shahabuddin, M., Wu, K. C.-W., Hossain, M. A., Yamauchi, Y. & Kim, J. Ho. (2017). Synthesis and cytotoxicity of dendritic platinum nanoparticles with HEK-293 cells. Chemistry - An Asian Journal, 12 (1), 21-26.

Abstract

Dendritic platinum nanoparticles (DPNs) have been synthesized from l-ascorbic acid and an amphiphilic non-ionic surfactant (Brij-58) via a sonochemical method. The particle size and shape of the DPNs could be tuned by changing the reduction temperature, resulting in a uniform DPN with a size of 23 nm or 60 nm. The facets of DPNs have been studied by high-resolution transmission electron microscopy. The cytotoxicity of DPNs has been investigated using human embryonic kidney cells (HEK-293), and the biological adaptability exhibited by DPNs has opened a pathway to biomedical applications such as drug-delivery systems, photothermal treatment, and biosensors.