Facile fabrication of dendritic mesoporous SiO2@CdTe@SiO2 fluorescent nanoparticles for bioimaging

Authors

Shaohua Zhang, University of WollongongFollow
Ling Wen, Soochow University, China
Jianping Yang, University of WollongongFollow
Jianfeng Zeng, Soochow University, China
Qiao Sun, Soochow University, ChinaFollow
Zhen Li, University of WollongongFollow
Dongyuan Zhao, Fudan University
S X. Dou, University of WollongongFollow

RIS ID

105825

Publication Details

Zhang, S., Wen, L., Yang, J., Zeng, J., Sun, Q., Li, Z., Zhao, D. & Dou, S. X. (2016). Facile fabrication of dendritic mesoporous SiO2@CdTe@SiO2 fluorescent nanoparticles for bioimaging. Particle and Particle Systems Characterization, 33 (5), 261-270.

Abstract

A seeded watermelon-like mesoporous nanostructure (mSiO2@CdTe@SiO2, mSQS) composed of a novel dendritic mesoporous silica core, fluorescent CdTe quantum dots (QDs), and a protective solid silica shell is successfully fabricated by loading QDs into dendritic mesoporous silica nanoparticles through electrostatic interaction, and then coating with a solid silica shell by the modified Stöber method. The shell thickness of mSQS can be tuned from 0 to 32 nm as desired by controlling the reaction parameters, including the amount of silica precursor, tetraethyl orthosilicate, that is introduced, the solvent ratio (H2O:ethanol), and the amount of catalyst (NH3·H2O). These fluorescent mSiO2@QDs@SiO2 nanoparticles possess excellent stability and thickness-dependent cytotoxicity, and are successfully applied to bioimaging. A seeded watermelon-like fluorescent mesoporous nanostructure (mSiO2@CdTe@SiO2) composed of a novel dendritic mesoporous silica core, fluorescent CdTe quantum dots, and a protective solid silica shell is successfully fabricated and applied to in vitro and in vivo bioimaging.