Controlled delivery of drugs adsorbed onto porous Fe3O4 structures by application of AC/DC magnetic fields

Authors

Mislav Mustapic, University Of WollongongFollow
Md Shahriar Hossain, University of WollongongFollow
Josip Horvat, University of WollongongFollow
Pawel W. Wagner, University of WollongongFollow
David R. G Mitchell, University of WollongongFollow
Jung Ho Kim, University of WollongongFollow
Gursel Alici, University of WollongongFollow
Yoshitaka Nakayama, Victor Chang Cardiac Research Institute (VCCRI)
Boris Martinac, St. Vincent's Hospital, Sydney, Victor Chang Cardiac Research Institute (VCCRI)

RIS ID

105318

Publication Details

Mustapic, M., Hossain, M. Al., Horvat, J., Wagner, P., Mitchell, D. R. G., Kim, J. Ho., Alici, G., Nakayama, Y. & Martinac, B. (2016). Controlled delivery of drugs adsorbed onto porous Fe3O4 structures by application of AC/DC magnetic fields. Microporous and Mesoporous Materials, 226 243-250.

Abstract

Porous structures made up of Fe3O4 nanoparticles were used to adsorb methyl blue in water. Controlled release of the methyl blue to water was then achieved by application of a magnetic field. Application of a pure DC field did not result in any release. Application of a pure AC field caused released of the methyl blue. However, a combination of both DC and AC fields resulted in much faster release. The mechanism by which this operated is believed to result from viscous friction. Nanoparticles are strongly aligned in the DC field and oscillate under the influence of the AC field. This study demonstrates a concept for controlled drug delivery, where pharmaceutical molecules, similar to methyl blue, would be adsorbed onto nanoporous Fe3O4 structure and the released at a target by application of appropriately localised magnetic fields.

Grant Number

ARC/DE130101247

Additional Grant Number

http://purl.org/au-research/grants/ARC/DE130101247