Thionation of amides using a solid-supported P2S5 reagent under microwave irradiation

Authors

Helen Rachel Lagiakos, Monash University
Ashley Walker, Monash UniversityFollow
Marie-Isabel Aguilar, Monash University
Patrick Perlmutter, Monash University

RIS ID

101540

Publication Details

Lagiakos, H., Walker, A., Aguilar, M. & Perlmutter, P. (2011). Thionation of amides using a solid-supported P₂S₅ reagent under microwave irradiation. Tetrahedron Letters: the international journal for the rapid publication of all preliminary communications in organic chemistry, 52 (40), 5131-5132.

Abstract

In this Letter, we describe an improved method for the thionation of amides. Using a solid-supported P₂S₅ reagent, heating under microwave irradiation furnished thioamides in good to excellent yields, with a significantly reduced reaction time compared with that achieved under conventional heating. Furthermore, a change of solvent from that described in the literature enabled a simplified work-up and purification of the products.