Targeting and uptake of multilayered particles to colorectal cancer cells

Authors

Christina Cortez, University of Melbourne
Eva Tomaskovic-Crook, University of WollongongFollow
Angus P. R Johnston, University of Melbourne
Benno Radt, University of Melbourne
Stephen H. Cody, Royal Melbourne Hospital
Andrew M. Scott, Austin Hospital, Royal Melbourne Hospital
Edouard C. Nice, Royal Melbourne Hospital
Joan K. Heath, Royal Melbourne Hospital
Frank Caruso, University of Melbourne

RIS ID

101139

Publication Details

Cortez, C., Tomaskovic-Crook, E., Johnston, A. P. R., Radt, B., Cody, S. H., Scott, A. M., Nice, E. C., Heath, J. K. & Caruso, F. (2006). Targeting and uptake of multilayered particles to colorectal cancer cells. Advanced Materials, 18 (15), 1998-2003.

Abstract

Core/shell particles and capsules formed by a layer-by-layer technique are biofunctionalized with a humanized A33 monoclonal antibody (huA33 mAb) that binds to the A33 antigen present on colorectal cancer cells (see figure). Targeting to a colorectal cancer cell line shows selective binding and internalization of particles.