Year

2014

Degree Name

Doctor of Philosophy

Department

School of Chemistry

Abstract

Carbohydrates have been heavily exploited in the development of new therapeutic agents. Extensively utilized in nuclear medicine, derivatives such as [18F]-FDG (13) have gained broad usage in the diagnosis of malignancies. Displaying high selectivity and favourable pharmacokinetics, carbohydrates have subsequently been incorporated into peptide-based imaging agents, producing diagnostic probes with greatly improved physicochemical properties. The efficient radiolabelling of glycoconjugate-based imaging agents however represents a significant challenge, with many glycoconjugates prone to degradation under current radiolabelling conditions.

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