Title

Alkaloids from the roots of stichoneuron caudatum and their acetylcholinesterase inhibitory activities

RIS ID

89835

Publication Details

Ramli, R. A., Lie, W. & Pyne, S. G. (2014). Alkaloids from the roots of stichoneuron caudatum and their acetylcholinesterase inhibitory activities. Journal of Natural Products, 77 (4), 894-901.

Abstract

Four new stichoneurine-type alkaloids, stichoneurines F and G (1-2) and sessilistemonamines E and F (3-4), have been isolated from the root extracts of Stichoneuron caudatum. The structures and relative configurations of these alkaloids have been determined by spectroscopic methods and molecular modeling experiments. Compounds 1-4 were tested for their acetylcholinesterase (AChE) inhibitory activities against human AChE. Compound 3 showed significant inhibitory activity with an IC50 value of 9.1 ± 0.15 μM.

Please refer to publisher version or contact your library.

Share

COinS
 

Link to publisher version (DOI)

http://dx.doi.org/10.1021/np400978x