Effects of olanzapine and betahistine on serotonin 5-HT2A receptor binding in the rat brain
Olanzapine is widely used in treating multiple domains of schizophrenia symptoms through its binding profile to various neurotransmitter receptors including a high antagonistic affinity to serotonergic 5-HT2A receptors (5-HT2AR). On the other hand, antagonistic affinity of olanzapine to histamine H1 receptors is a main indicator of its weight gain/obesity side effects.
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