Title

Three-dimensional neural cultures produce networks that mimic native brain activity

RIS ID

122059

Publication Details

Bourke, J. L., Quigley, A. F., Duchi, S., O'Connell, C. D., Crook, J. M., Wallace, G. G., Cook, M. J. & Kapsa, R. (2018). Three-dimensional neural cultures produce networks that mimic native brain activity. Journal of Tissue Engineering and Regenerative Medicine, 12 (2), 490-493.

Abstract

Development of brain function is critically dependent on neuronal networks organized through three dimensions. Culture of central nervous system neurons has traditionally been limited to two dimensions, restricting growth patterns and network formation to a single plane. Here, with the use of multichannel extracellular microelectrode arrays, we demonstrate that neurons cultured in a true three-dimensional environment recapitulate native neuronal network formation and produce functional outcomes more akin to in vivo neuronal network activity.

Grant Number

ARC/CE140100012

Grant Number

NHMRC/1062569

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