Title

Synthesis and cytotoxicity of dendritic platinum nanoparticles with HEK-293 cells

RIS ID

110995

Publication Details

Shim, K., Kim, J., Heo, Y., Jiang, B., Li, C., Shahabuddin, M., Wu, K. C.-W., Hossain, M. A., Yamauchi, Y. & Kim, J. Ho. (2017). Synthesis and cytotoxicity of dendritic platinum nanoparticles with HEK-293 cells. Chemistry - An Asian Journal, 12 (1), 21-26.

Abstract

Dendritic platinum nanoparticles (DPNs) have been synthesized from l-ascorbic acid and an amphiphilic non-ionic surfactant (Brij-58) via a sonochemical method. The particle size and shape of the DPNs could be tuned by changing the reduction temperature, resulting in a uniform DPN with a size of 23 nm or 60 nm. The facets of DPNs have been studied by high-resolution transmission electron microscopy. The cytotoxicity of DPNs has been investigated using human embryonic kidney cells (HEK-293), and the biological adaptability exhibited by DPNs has opened a pathway to biomedical applications such as drug-delivery systems, photothermal treatment, and biosensors.

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Link to publisher version (DOI)

http://dx.doi.org/10.1002/asia.201601239