Year

2020

Degree Name

Master of Philosophy

Department

School of Medicine

Abstract

An adverse drug event (ADE) for this thesis is defined as harm from a medication resulting in hospitalisation. Oral anticoagulants are among the most common drugs worldwide which contribute to medication-related ADEs. These oral anticoagulants include the non-vitamin K antagonist oral anticoagulant (NOACs) and warfarin, a vitamin K antagonist. According to the evidence, there are conflicting studies which have cited significant and non-significant differences between NOACs and warfarin, with regard to ADEs, including haemorrhage, ischaemic stroke and venous thromboembolism (VTE). The majority of these studies have been clinical trials and do not include post-marketing surveillance. This thesis compares population-adjusted rates and risk of ADEs for NOACs (apixaban and rivaroxaban) and warfarin for a cohort of patients residing in the Illawarra Shoalhaven region of NSW. In addition, this study investigated potential contributing factors for oral anticoagulant-related ADEs resulting in hospitalisation.

This thesis is unavailable until Tuesday, July 20, 2021

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Unless otherwise indicated, the views expressed in this thesis are those of the author and do not necessarily represent the views of the University of Wollongong.