Year

2020

Degree Name

Doctor of Philosophy

Department

School of Chemistry & Molecular Bioscience And The Illawarra Health & Medical Research Institute

Abstract

Nearly all biological systems require proteins to achieve and maintain their native, threedimensional conformation, however, various stresses and genetic mutations can cause proteins to misfold and aggregate. Both intracellular and extracellular protein aggregates are associated with protein deposition diseases (PDDs), such as Alzheimer’s disease (AD), Parkinson’s disease (PD), and amyotrophic lateral sclerosis (ALS). Although the processes involved in maintaining intracellular protein quality control are well established, much less is known regarding the maintenance of extracellular proteostasis...

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Unless otherwise indicated, the views expressed in this thesis are those of the author and do not necessarily represent the views of the University of Wollongong.