Doctor of Philosophy
School of Chemistry & Molecular Bioscience And The Illawarra Health & Medical Research Institute
Nearly all biological systems require proteins to achieve and maintain their native, threedimensional conformation, however, various stresses and genetic mutations can cause proteins to misfold and aggregate. Both intracellular and extracellular protein aggregates are associated with protein deposition diseases (PDDs), such as Alzheimer’s disease (AD), Parkinson’s disease (PD), and amyotrophic lateral sclerosis (ALS). Although the processes involved in maintaining intracellular protein quality control are well established, much less is known regarding the maintenance of extracellular proteostasis...
West, Jennifer Renee, Extracellular Chaperones and their Cell Surface Receptors, Doctor of Philosophy thesis, School of Chemistry & Molecular Bioscience And The Illawarra Health & Medical Research Institute, University of Wollongong, 2020. https://ro.uow.edu.au/theses1/832
Unless otherwise indicated, the views expressed in this thesis are those of the author and do not necessarily represent the views of the University of Wollongong.