Master of Science (Medical Radiation Physics)
School of Physics
BrachyView is a novel in-body imaging system, aimed to accurately localise brachytherapy sources using high-resolution pixelated silicon detectors and a pinhole collimator. In the recent years, many research projects have studied the different possibilities for real-time, intra-operative, dynamic dose treatment planning to increase the quality of brachytherapy implants. The capabilities of this pinhole camera were tested through a proof of concept study using four active seeds. A more clinically realistic scenario, using twenty active seeds implanted in a PMMA phantom, was the clear next step. To further imitate a clinical scenario, 20 seeds were implanted and imaged using a single pinhole lead collimator with a diameter of 400 μm. BrachyView was successful at locating the seeds within 1-2 mm of their expected positions which was verified via co-registration with a full clinical post-implant CT scan with 0.8 mm width. The first BrachyView prototype to feature a triple-chip detector embedded within a tungsten collimator with three single cone pinholes was used to localise 30 active seeds embedded within 11 needles, implanted in a soft gel prostate phantom, under ultrasound guidance. For verification, a full post implant CT was also performed. The BrachyView was able to accurately resolve the all the seeds with a maximum discrepancy of 1.78 mm
Jalayer, Masoud, An Innovative Approach to Intraoperative Quality Assurance for Low Dose Rate Brachytherapy, Master of Science (Medical Radiation Physics) thesis, School of Physics, University of Wollongong, 2020. https://ro.uow.edu.au/theses1/815
Unless otherwise indicated, the views expressed in this thesis are those of the author and do not necessarily represent the views of the University of Wollongong.