Degree Name

Doctor of Philosophy


School of Physics


Radiotherapy benefits half of all cancer patients in the management of their disease. Several studies have shown dose escalation and hypofractionation leads to better tumour control for lung and prostate cancers. The large dose encountered in these treatments has the potential to increase toxicity to surrounding organs, especially for lung and prostate patients, due to tumour motion during treatment. The limiting factor for expanding the use of techniques such as stereotactic ablative radiotherapy (SABR) is toxicity.

Real-time adaptive radiotherapy re-configures the radiation beam during treatment in response to the moving patient anatomy. This allows treatment margins to be reduced and the resulting dose distribution is highly conformal to the moving tumour. Depending on the patient motion of the day, the delivered dose may not match the planned dose. Careful quality assurance processes are required to quantify the dose to the target as well as organs at risk during real-time adaptive radiotherapy.



Unless otherwise indicated, the views expressed in this thesis are those of the author and do not necessarily represent the views of the University of Wollongong.