Year

2019

Degree Name

Doctor of Philosophy

Department

School of Physics

Abstract

The body of work presented in this thesis is related to the development and efficacy of new and multimodal treatments for cancer. The relative cytotoxicity as well as selectivity of such modalities is assessed through various cell assay techniques (in- cluding clonogenic assay) by involving separate and co-cultured cell experiments. Two cancer cell lines are used in these studies, the very radioresistant 9L cell line (gliosarcoma brain cancer model) and the Michigan Cancer Foundation-7 (MCF7) cell line (invasive breast ductal carcinoma model). In addition, and where relevant, the Madin-Darby Canine Kidney (MDCK) cell line was also studied as an example of a non-cancerous cell in vitro model for compound, drug and/or nanoparticle ex- posure as well as multimodal treatment response.

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Unless otherwise indicated, the views expressed in this thesis are those of the author and do not necessarily represent the views of the University of Wollongong.