Doctor of Philosophy
School of Chemistry and Molecular Bioscience
Sialic acids are negatively charged sugars that are often located at the terminal end of glycan chains on cell surface and secreted molecules, allowing them to play crucial roles in cellular biology. Sialyltransferases are enzymes of the glycosyltransferase family that play an integral role in the biosynthesis of sialic acid containing oligosaccharides and glycoconjugates. Abnormal sialylation is strongly associated with cancer, with hypersialylation of up to 30–40% observed, along with significant upregulation of sialyltransferase activity. This has been directly correlated with an increased metastatic potential of tumours, avoidance of apoptotic pathways and resistance to therapy...
Montgomery, Andrew Peter, Rational Design of Inhibitors Targeting Human Sialyltransferases, Doctor of Philosophy thesis, School of Chemistry and Molecular Bioscience, University of Wollongong, 2019. https://ro.uow.edu.au/theses1/507
Unless otherwise indicated, the views expressed in this thesis are those of the author and do not necessarily represent the views of the University of Wollongong.