Doctor of Philosophy
Centre for Medical Radiation Physics
Al Shukaili, Khalsa Ali, 2D Monolithic silicon detectors for dosimetry in Small beam radiotherapy (Stereotactic Radiotherapy), Doctor of Philosophy thesis, Centre for Medical Radiation Physics, University of Wollongong, 2018. https://ro.uow.edu.au/theses1/302
Radiation Therapy is one type of cancer’s treatment, which aims to kill or control tumour cells by using high energy radiation. However, it can affect both normal and tumour cells. Due to that, scientists worked to develop a new treatment technique of radiation delivery that focuses the high prescribed dose on the small localized area of tumour cells and protects the normal cells. This focal irradiation technique is called Stereotactic Radiosurgery (SRS). Using SRS allows the treatment of hard-to-reach lesions where surgery is not possible because of the risks resulting in the surgical procedures. The commissioning and Quality Assurance of SRS/SRT is complex and requires special dosimetry tools. Poor dosimetry of small-field characteristics may lead to reduced treatment efficacy, whether by under-dosage of targeted tumours or overirradiation of adjacent healthy tissues. Poor measurements of the small field characteristics, such as FWHM, penumbra width, output factors and percentage depth dose may result in pernicious health consequences, such as radiation-induced carcinogenesis. Hence, the dosimetry tool plays an important role in the SRS/SRT accuracy and precise delivery. Recently, silicon detectors have increased in popularity because they have high spatial resolution, small sensitive volume, high sensitivity to radiation, reasonable uniformity and provides real time measurements. The Centre for Medical Radiation Physics (CMRP) has developed two innovative monolithic silicon array detectors, DUO and OCTA, to be used in SRS/SRT for pretreatment quality assurance dosimetry. Therefore, the aim of this thesis is to characterise these two monolithic silicon detectors for small radiation field dosimetry employed in stereotactic radiotherapy.