Year
2023
Degree Name
Doctor of Philosophy
Department
Intelligent Polymer Research Institute
Abstract
Gelatin based hydrogels such as gelatin-methacryloyl (GelMA) have been widely explored in literature, to create 3D environments for cell culture. Collagen is the natively occurring protein, from which gelatin is obtained by denaturation. Collagen is the main protein component of the extra cellular matrix, and provides structural and signalling roles. Such collagen hydrogels have been utilised in tissue engineering to recapitulate the 3D environment found in vivo.
While the use of collagen hydrogels is increasing in the field of tissue engineering, the vast array of collagens available are used interchangeably without an understanding of how they differ. While utilising the native fibril forming process is common, exploring various alternative crosslinking methods offers the ability to 3D printing and fabricate complex scaffolds which can be advantageous to tissue engineering.
Recommended Citation
Maher, Malachy Kevin, Evaluation of collagen hydrogels for 3D printing and tissue engineering applications, Doctor of Philosophy thesis, Intelligent Polymer Research Institute, University of Wollongong, 2023. https://ro.uow.edu.au/theses1/1899
FoR codes (2008)
0303 MACROMOLECULAR AND MATERIALS CHEMISTRY, 0601 BIOCHEMISTRY AND CELL BIOLOGY, 0903 BIOMEDICAL ENGINEERING, 0912 MATERIALS ENGINEERING
Unless otherwise indicated, the views expressed in this thesis are those of the author and do not necessarily represent the views of the University of Wollongong.