Degree Name

Doctor of Philosophy


School of Medical, Indigenous and Health Sciences


Alzheimer's disease (AD) is a degenerating neural connectivity disorder that results in memory loss and cognitive impairment. The accumulation of amyloid-β (Aβ) in the brain is the first pathological mechanism to initiate AD pathogenesis. However, the precise role of Aβ in the disease progression remains unclear. Thus, it is of high importance to determine the exact role of Aβ throughout the entire course of AD to treat or possibly prevent AD progression.

FoR codes (2008)

0601 BIOCHEMISTRY AND CELL BIOLOGY, 060104 Cell Metabolism



Unless otherwise indicated, the views expressed in this thesis are those of the author and do not necessarily represent the views of the University of Wollongong.