Degree Name

Doctor of Philosophy


School of Psychology


P50 suppression is a measure of the brain’s ability to modulate its response to incoming repetitive auditory stimuli that is derived from the electroencephalogram. This measure is widely used in psychiatric research and is argued to be a schizophrenia endophenotype. However, inconsistent results within this literature suggest that P50 suppression, even in healthy populations, is poorly understood and limits the ‘endophenotype’ claim. An understanding of methodological issues relevant to P50 suppression measurement, variables influencing P50 suppression, and the neural function it indexes in healthy subjects will inform psychiatric research as to the nature of impairments observed in schizophrenia.



Unless otherwise indicated, the views expressed in this thesis are those of the author and do not necessarily represent the views of the University of Wollongong.