Degree Name

Doctor of Philosophy


School of Chemistry


All forms of life are defined by their DNAs. For organisms to survive, their chromosomes have to be replicated authentically and passed onto their next generations. This process is very complex – it involves a large number of proteins working in a very dynamic way. By elucidating this system, it helps us understand the basic mechanisms underlying life, to the eventual benefit of human beings.

This Thesis contributes to the understanding of E. coli DNA replication by revealing and defining numerous protein–protein and protein–DNA interactions biochemically and structurally. Importantly, it also provides insights into new protein–protein and protein–DNA interactions.

FoR codes (2008)

060107 Enzymes, 060112 Structural Biology (incl. Macromolecular Modelling)



Unless otherwise indicated, the views expressed in this thesis are those of the author and do not necessarily represent the views of the University of Wollongong.