Year
1995
Degree Name
Master of Science (Hons.)
Department
Department of Biological Sciences
Recommended Citation
Newman, R. E., Physiological adaptations to acute stress in the ewe, Master of Science (Hons.) thesis, Department of Biological Sciences, University of Wollongong, 1995. https://ro.uow.edu.au/theses/2750
Abstract
An investigation of the two major stress pathways, the sympathomedullary system, and the hypothaiamic-pituitary-adrenal (HPA) axis and their role in the mediation of the physiological response to acute stress was undertaken in the sheep. Particular emphasis was given to the metabolic regulation initiated by these two stress pathways. In addition, the specific role of each pathway was assessed. This was achieved by using two different approaches. Firstly, by the active immunisation against ACTH 1-24, which acts to immunoneutralise the glucocorticoid response. Secondly, a pharmacological approach using non-selective adrenergic receptor antagonists. Propranolol HCI, a yff-adrenergic antagonist and phentolamine methane-sulfonate, a or-adrenergic antagonist were used. To determine the contribution of the sympathetic nervous system tyramine HCI, a potent sympathomimeteic agonist compound was infused into sheep.
Unless otherwise indicated, the views expressed in this thesis are those of the author and do not necessarily represent the views of the University of Wollongong.