Year
2008
Degree Name
Master of Science - Research
Department
School of Chemistry, Faculty of Science
Recommended Citation
Ramachandran, Aravind, Experimental and computational studies of the unimolecular rearrangements of sulphonated azo dyes and phenoxide anions in the gas-phase, Master of Science - Research thesis, School of Chemistry, Faculty of Science, University of Wollongong, 2008. https://ro.uow.edu.au/theses/2625
Abstract
The tandem mass spectrometer is an ideal tool to probe unimolecular reactions of ions. Of particular interest are reactions involving skeletal rearrangement of ions prior to dissociation. Given that such unimolecular reactions occur in the absence of complicating factors such as solvent and counter ions, within the vacuum environment of the mass spectrometer, computational methods employing molecular orbital and density functional theories are ideally suited to examine the reaction mechanisms. A surprising rearrangement was identified by electrospray ionization tandem mass spectrometry of anions of azo dyes and the rearrangement was found to effect a loss of the azo moiety bridging aromatic rings as nitrogen. Even though the fragmentation reaction was previously reported, we are unaware of any conclusive mechanistic study. In the present thesis, by combination of tandem mass spectrometry and computational methods, we have identified that the rearrangement proceeds via an initial tautomerization, followed by nucleophilic aromatic substitution reaction (Scheme- 1). NH2 SO3 N N SO3 NH N HN SO3 HN NH N SO3 N HN N H SO3 HN -N2 H SO3 HN Scheme-1 For the past two decades, phenoxide anions were reported to undergo unimolecular fragmentation resulting in the loss of CO. The present thesis presents an electronic structure calculation study on this unimolecular fragmentation, where in it was ix identified that the loss of CO occurs via reaction pathways involving ketene like intermediates and transition states (Scheme-2). O C O O C + CO H H C O C O C O + CO H C O C O C O C O H Scheme-2
02Whole.pdf (4668 kB)
Unless otherwise indicated, the views expressed in this thesis are those of the author and do not necessarily represent the views of the University of Wollongong.