Global mortality associated with 33 bacterial pathogens in 2019: a systematic analysis for the Global Burden of Disease Study 2019


Kevin S. Ikuta, VA Medical Center
Lucien R. Swetschinski, Institute for Health Metrics and Evaluation
Gisela Robles Aguilar, Nuffield Department of Medicine
Fablina Sharara, Independent Consultant
Tomislav Mestrovic, Institute for Health Metrics and Evaluation
Authia P. Gray, Institute for Health Metrics and Evaluation
Nicole Davis Weaver, Institute for Health Metrics and Evaluation
Eve E. Wool, Institute for Health Metrics and Evaluation
Chieh Han, Institute for Health Metrics and Evaluation
Anna Gershberg Hayoon, Institute for Health Metrics and Evaluation
Amirali Aali, Mashhad University of Medical Sciences, School of Medicine
Semagn Mekonnen Abate, Dilla University
Mohsen Abbasi-Kangevari, Non-Communicable Diseases Research Center
Zeinab Abbasi-Kangevari, Non-Communicable Diseases Research Center
Sherief Abd-Elsalam, Tanta University
Getachew Abebe, Arba Minch University
Aidin Abedi, University of Southern California
Amir Parsa Abhari, School of Medicine, Isfahan UMS
Hassan Abidi, Yasuj University of Medical Sciences
Richard Gyan Aboagye, University of Health and Allied Sciences, Ghana
Abdorrahim Absalan, Khomein University of Medical Sciences
Hiwa Abubaker Ali, University of Human Development
Juan Manuel Acuna, Khalifa University of Science and Technology
Tigist Demssew Adane, Rijksuniversiteit Groningen
Isaac Yeboah Addo, UNSW Sydney
Oyelola A. Adegboye, James Cook University
Mohammad Adnan, Ball Memorial Hospital
Qorinah Estiningtyas Sakilah Adnani, Universitas Padjadjaran
Muhammad Sohail Afzal, University of Management and Technology Lahore

Publication Name

The Lancet


Background: Reducing the burden of death due to infection is an urgent global public health priority. Previous studies have estimated the number of deaths associated with drug-resistant infections and sepsis and found that infections remain a leading cause of death globally. Understanding the global burden of common bacterial pathogens (both susceptible and resistant to antimicrobials) is essential to identify the greatest threats to public health. To our knowledge, this is the first study to present global comprehensive estimates of deaths associated with 33 bacterial pathogens across 11 major infectious syndromes. Methods: We estimated deaths associated with 33 bacterial genera or species across 11 infectious syndromes in 2019 using methods from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019, in addition to a subset of the input data described in the Global Burden of Antimicrobial Resistance 2019 study. This study included 343 million individual records or isolates covering 11 361 study-location-years. We used three modelling steps to estimate the number of deaths associated with each pathogen: deaths in which infection had a role, the fraction of deaths due to infection that are attributable to a given infectious syndrome, and the fraction of deaths due to an infectious syndrome that are attributable to a given pathogen. Estimates were produced for all ages and for males and females across 204 countries and territories in 2019. 95% uncertainty intervals (UIs) were calculated for final estimates of deaths and infections associated with the 33 bacterial pathogens following standard GBD methods by taking the 2·5th and 97·5th percentiles across 1000 posterior draws for each quantity of interest. Findings: From an estimated 13·7 million (95% UI 10·9–17·1) infection-related deaths in 2019, there were 7·7 million deaths (5·7–10·2) associated with the 33 bacterial pathogens (both resistant and susceptible to antimicrobials) across the 11 infectious syndromes estimated in this study. We estimated deaths associated with the 33 bacterial pathogens to comprise 13·6% (10·2–18·1) of all global deaths and 56·2% (52·1–60·1) of all sepsis-related deaths in 2019. Five leading pathogens—Staphylococcus aureus, Escherichia coli, Streptococcus pneumoniae, Klebsiella pneumoniae, and Pseudomonas aeruginosa—were responsible for 54·9% (52·9–56·9) of deaths among the investigated bacteria. The deadliest infectious syndromes and pathogens varied by location and age. The age-standardised mortality rate associated with these bacterial pathogens was highest in the sub-Saharan Africa super-region, with 230 deaths (185–285) per 100 000 population, and lowest in the high-income super-region, with 52·2 deaths (37·4–71·5) per 100 000 population. S aureus was the leading bacterial cause of death in 135 countries and was also associated with the most deaths in individuals older than 15 years, globally. Among children younger than 5 years, S pneumoniae was the pathogen associated with the most deaths. In 2019, more than 6 million deaths occurred as a result of three bacterial infectious syndromes, with lower respiratory infections and bloodstream infections each causing more than 2 million deaths and peritoneal and intra-abdominal infections causing more than 1 million deaths. Interpretation: The 33 bacterial pathogens that we investigated in this study are a substantial source of health loss globally, with considerable variation in their distribution across infectious syndromes and locations. Compared with GBD Level 3 underlying causes of death, deaths associated with these bacteria would rank as the second leading cause of death globally in 2019; hence, they should be considered an urgent priority for intervention within the global health community. Strategies to address the burden of bacterial infections include infection prevention, optimised use of antibiotics, improved capacity for microbiological analysis, vaccine development, and improved and more pervasive use of available vaccines. These estimates can be used to help set priorities for vaccine need, demand, and development. Funding: Bill & Melinda Gates Foundation, Wellcome Trust, and Department of Health and Social Care, using UK aid funding managed by the Fleming Fund.

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Funding Sponsor

National Institutes of Health



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