SECONDARY METABOLITE ISOLATION FROM INDONESIAN FOLIOUS LICHEN: Phyloporon aciculare (Ach.) Nyl

Publication Name

Rasayan Journal of Chemistry

Abstract

Lichen has been investigated for discovering new antibacterial agents. Although Indonesia is considered one of the megadiverse countries and a home to a diverse array of lichen species, research on lichens for medicinal properties remains scarce. In this study, an intensive semi-preparative High-Performance Liquid Chromatography successfully isolated a major compound from Phyloporon aciculare, with its molecular structure proposed as methyl 2,4-dihydroxy-3,6-dimethylbenzoate by Nuclear Magnetic Resonance spectral and was confirmed by Mass Spectrometry data analysis. The crude extract of the lichen possessed a selective antibacterial activity in which significantly inhibited Kocuria rhizophila by 96.9% at a 100 µg/mL concentration. In addition, previous reports on methyl 2,4-dihydroxy-3,6-dimethylbenzoate from other species indicated the compound to have antibacterial, anti-inflammatory, and anticancer activities.

Open Access Status

This publication may be available as open access

Volume

15

Issue

4

First Page

2685

Last Page

2691

Funding Number

68121

Funding Sponsor

University of Wollongong

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Link to publisher version (DOI)

http://dx.doi.org/10.31788/RJC.2022.1548027