Title

Insights into the role of sialylation in cancer progression and metastasis

Publication Name

British Journal of Cancer

Abstract

Upregulation of sialyltransferases—the enzymes responsible for the addition of sialic acid to growing glycoconjugate chains—and the resultant hypersialylation of up to 40–60% of tumour cell surfaces are established hallmarks of several cancers, including lung, breast, ovarian, pancreatic and prostate cancer. Hypersialylation promotes tumour metastasis by several routes, including enhancing immune evasion and tumour cell survival, and stimulating tumour invasion and migration. The critical role of enzymes that regulate sialic acid in tumour cell growth and metastasis points towards targeting sialylation as a potential new anti-metastatic cancer treatment strategy. Herein, we explore insights into the mechanisms by which hypersialylation plays a role in promoting metastasis, and explore the current state of sialyltransferase inhibitor development.

Open Access Status

This publication is not available as open access

Volume

124

Issue

1

First Page

76

Last Page

90

Funding Sponsor

University of Wollongong

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Link to publisher version (DOI)

http://dx.doi.org/10.1038/s41416-020-01126-7