Overview of inflammation

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Recent Advancements in Microbial Diversity: Macrophages and their Role in Inflammation


In this chapter, we introduce the basic concepts of inflammation. First, you will learn the immunological meaning of inflammation. It acts as an important barrier in innate immunity. Inflammation can be induced after activation of innate immune cells such as macrophages to remove invasive extracellular pathogens and repair wounds and damaged organs. Inflammation triggers four cardinal signs, that is, heat, swelling, pain, and loss of function in the body, by inducing many different inflammatory mediators. Although inflammation is a natural defense mechanism, most human diseases such as cancer and diabetes are caused by acute and chronic inflammatory responses. Because of the pathophysiological features of inflammation, multiple different types of antiinflammatory medicines have been developed and are widely used in the clinic.

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